Tuesday, January 12, 2021

Global – 89,400,000/1,900,000; USA – 22,500,000/375,100 4400 deaths today John Mascola working with David Ho to determine the possibility that the UK (N501Y; B.1.1.7) and/or the RSA mutants evade the antibodies induced by vaccines. According to Ho, the RSA mutants are much more troublesome in that they do not eliminate the protection of vaccine induced antibodies, but they definitely decrease by 2 to 3-fold their potency. David is now working on studying the UK mutant. Stay tuned. The next 4 weeks will be determined by whether the large Southern, upper Mid-West, Mid-Atlantic and North-East metros will be able to contain the rapid accelerating viral spread or have the prolonged log phase followed by the high plateau of LA (now entering month 3). Deb 1. Reporting has stabilized and we have returned to the rapid pre-thanksgiving rate of cases as the current resurgence moves into the populous states from CA to TX to FL : cases are up 7% from last week's same time period. 2. Nearly all METROs over 500K residents is deteriorating. - even those that had been stable now have rising cases slides 7-45: NYC area is now reached cases greater than the Spring surge Throughout “the 2019 flu season from Sept. 29 to Dec. 28, the CDC reported more than 65,000 cases of influenza nationwide,” while “during the same period last year, the agency reported 1,016 cases.” • Had discussion with Chris Whitty and Patrick Vallance of the UK regarding their mutant and their vaccine program. They confirmed that the mutant is spreading widely in UK and other EU countries and also that there is no increase in virulence of escape from vaccine-induced antibodies. They also mentioned that they are more concerned about the RSA variant (mutants). • Did Fireside Chat with Barbara Bush on “Future Forum for Preparedness” (her Global Health Corps) Had discussion with Azar, Pence, and the OWS crew about vaccine rollout. We will as of tomorrow (announce at the Governor’s call) that we are changing our rollout strategy. We are going to be more flexible and not strictly wedded to the ACIP/CDC guidance of Phase 1a. We should continue that, but move on the people >65 years old and people 16 (or 18) to 64 with underlying conditions Am communicating with Stanley Tucci. He has heard through the media that I make Tympani: From: Stanley Tucci <sta914@gmail.com> Sent: Tuesday, January 12, 2021 2:28 PM To: Fauci, Anthony (NIH/NIAID) [E] <afauci@niaid.nih.gov> Cc: Lottie Birmingham <lottie.birmingham@icloud.com> Subject: Re: Stanley Tucci and Timpano Dr. Fauci, Thank you so much for your timely response and your kind words. The books will be whisking their way towards you imminently. It is my hope that someday we might prepare and enjoy a Timpano together. All the best to you and your family. With great respect and admiration, Stan On 12 Jan 2021, at 6:54 pm, Fauci, Anthony (NIH/NIAID) [E] <afauci@niaid.nih.gov> wrote: Mr. Tucci: Thank you for your very kind note. I was thrilled to hear from as I am a great fan of your acting and am looking forward to watching your CNN Special. I would be honored if you could send me autographed copies of your cook books. My address is 3012 – 43rd Street, NW; Washington, DC 20016. I hope that you are doing well during these difficult times. Please stay safe. Warm regards, Tony Jeff Zients called me to get approval of a statement that Biden will put out criticizing the Trump administration for opening up the floodgates of the Phases for vaccines (see above) given that there is not enough vaccine to go around at this point. Indicated that I did not like the statement sine it was a gotcha. Jeff did not like that but nonetheless changed it somewhat according to my suggestions. Here Are 18 Celebrities (And Public PRESS: Figures) Who Have Gotten The Coronavirus Vaccine From politicians to performers. by Matt Stopera BuzzFeed Staff